A Hemorrhagic Disease Occurring in Chicks Inoculated with the Rous and Fuginami Viruses *

In the preceding paper' it was shown that antibody-like factors, endowed with a suppressing power for viruses inducing tumors in the fowl, are present in the blood serum of a great majority of adult chickens, while they are generally lacking in the sera of chicks and pullets. The next logical step was to compare the reaction induced by such viruses injected into the blood stream of chicks with reactions induced by similar inoculations in adult chickens. In the present study it will be shown that the disease induced in the chick by tumor viruses injected intravenously is an acute generalized and hemorrhagic condition in which frequently those gross features whereby neoplasms are recognized cannot be detected. The problem of metastasis formation will also be approached.